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Effects of lovastatin on the immune system.

Author(s): Muldoon MF, Flory JD, Marsland A, Manuck SB, Whiteside TL, Rabin B

Affiliation(s): Center for Clinical Pharmacology, University of Pittsburgh Cancer Institute, Pennsylvania 15260, USA.

Publication date & source: 1997-11-15, Am J Cardiol., 80(10):1391-4.

Publication type: Clinical Trial; Randomized Controlled Trial

Laboratory investigations have demonstrated that blockade of HMG-CoA reductase in vitro reduces lymphocyte proliferation in response to mitogens as well as other facets of the immune system, such as natural killer cell cytotoxicity. However, in this randomized and double-blind clinical investigation, treatment with 20-mg lovastatin for 6 months did not significantly alter several enumerative and functional characteristics of circulating immune cells.

Page last updated: 2006-01-31

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