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Two regimens of lithium prophylaxis and renal function.

Author(s): Muir A, Davidson R, Silverstone T, Dawnay A, Forsling ML

Affiliation(s): Academic Unit of Human Psychopharmacology, Medical College of St Bartholomew's Hospital, London, United Kingdom.

Publication date & source: 1989-12, Acta Psychiatr Scand., 80(6):579-83.

Publication type: Clinical Trial; Randomized Controlled Trial; Research Support, Non-U.S. Gov't

Two regimens of lithium prophylaxis with different pharmacokinetic characteristics were compared under double-blind conditions in 25 bipolar patients in remission already stabilized on lithium, to determine the relative effects of each regimen on renal function. Once-daily lithium carbonate (Priadal), which gives a peak lithium plasma level 2-3 h post-administration with a low level 24 h later, was compared with twice-daily lithium citrate (Litarex), which maintains a steadier 24 h plasma level. Patients were allocated randomly to one of the 2 regimens. They were seen monthly for clinical ratings over the course of 12 months. A comprehensive battery of renal function tests was undertaken at the start of the trial, between 6-9 months after the start and again after 1 year. No significant differences were observed in clinical outcome, side effects or renal function between the 2 regimens.

Page last updated: 2007-10-18

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