Pharmacokinetics of triamterene in geriatric patients--influence of piretanide and hydrochlorothiazide.

Author(s): Muhlberg W, Spahn H, Platt D, Mutschler E, Jung R

Affiliation(s): Institute of Gerontology, University of Erlangen-Nuremberg, FRG.

Publication date & source: 1989-01, Arch Gerontol Geriatr., 8(1):73-85.

Publication type:

Pharmacokinetics of triamterene (single oral dose of 50 mg) and its pharmacologically active metabolite (OH-TA-ester) were determined in 20 geriatric patients with multiple diseases. Mean peak concentration of triamterene was increased in the elderly patients compared with the data of young healthy volunteers. Coadministration of piretanide seems to lower the mean plasma concentration (AUC) and the mean concentration after 24 h of triamterene as compared with the coadministration of hydrochlorothiazide.