[Efficacy of nitrofurantoin in the treatment of chronic urinary tract infections in patients with type 2 diabetes mellitus]

Author(s): Mozdzan M, Ruxer J, Siejka A, Loba J, Markuszewski L

Affiliation(s): Departement of Interventional Cardiology, Cardiodiabetology and Cardiac Rehabilitation, Medical University of lodz, Poland. mozdzanm@poczta.onet.pl

Publication date & source: 2006-11, Pol Merkur Lekarski., 21(125):434-8.

Publication type: Controlled Clinical Trial; English Abstract

THE AIM: of this study was to comprise the efficacy of chronic therapy with nitrofuarntoin in the treatment and prevention of recurrent urinary tract infections (NIM) in type 2 diabetic women. MATERIALS AND METHODS: The study comprised 105 women aged 50-70 years, who suffered from the NIM (isolated bacterial uropathogen sensitive to nitrofurantoin and cotrimoxazole). Women were divided into two groups. Group 1 (n=55) consisted of patients, who have been treated with nitrofurantoin and group 2 - control group (n=50) with cotromixazole. Observation period lasted 12 months and for the 9 months patients were treated with antimicrobial agents. Efficacy of antimicrobial treatment was estimated when both clinical cure and bacteriological eradication of uropathogens were achieved. RESULTS: There were no significant differences in the percentage of patients between study groups, who achieved therapeutic successes after three, six and nine months of the antimicrobial treatment (NS). Three months after discontinuation of this treatment episodes of NIM were observed in similar frequency in two study groups (NS). CONCLUSION: Nitrofurantoin is the effective antimicrobial method to cure and prevent NIM.