Development of amitriptyline buccoadhesive tablets for management of pain in dental procedures.
Author(s): Movassaghian S, Barzegar-Jalali M, Alaeddini M, Hamedyazdan S, Afzalifar R, Zakeri-Milani P, Mohammadi G, Adibkia K
Affiliation(s): Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran.
Publication date & source: 2011-07, Drug Dev Ind Pharm., 37(7):849-54. Epub 2011 Jan 14.
Publication type: Randomized Controlled Trial; Research Support, Non-U.S. Gov't
Administration of lidocaine and nonsteroidal anti-inflammatory drugs (NSAIDs) as a routine procedure for relief of dental pains by and large is restricted due to some side effects. Amitriptyline (AM) has long been known to exert analgesic activity as a result of blocking the Na channels. The objective of the present investigation was to prepare suitable buccoadhesive tablets using cellulose derivatives in order to obtain new formulations containing AM to provide local analgesic action. The tablets were evaluated in terms of physical characteristics, mucoadhesion performance, drug release, and in vivo assessment of analgesic efficiency. Tablets containing higher amounts of high-viscosity hydroxypropylmethyl cellulose (HPMC-K4M) significantly demonstrated enhanced adhesive performances. On the other hand, presence of sodium carboxymethyl cellulose (NaCMC) in formulations including HPMC of lower-viscosity grade (HPMC-E5LV) provided further adhesiveness by increase in viscosity. Rate of drug release from HPMC-E5LV tablets was significantly higher than the HPMC-K4M tablets. Kinetically, patterns of AM release from the tablets fitted best to Higuchi model. Moreover, in a randomized double-blind trial, analgesic efficiency of the prepared bioadhesive tablets was revealed to be satisfactory. It is suggested that applying the topical AM mucoadhesive tablet containing the low amount of drug is a safe and promising alternative to relief the pain in the buccal region.