Can isosorbide mononitrate be useful in second trimester termination of
pregnancies?
Author(s): Mousiolis A(1), Sindos M, Papantoniou N, Antsaklis A.
Affiliation(s): Author information:
(1)1st Department of Obstetrics and Gynecology, Alexandra Maternity Hospital,
University of Athens, Athens, Greece. thanasism@yahoo.com
Publication date & source: 2013, Contraception. , 88(1):41-4
BACKGROUND: Isosorbide mononitrate (IMN) administration is thought to enhance in
the cervical ripening process. We sought to identify the clinical usefulness and
safety of IMN administration for shortening the time to termination of the second
trimester pregnancy procedures when used in addition to misoprostol.
STUDY DESIGN: Women were randomly selected to receive either the standard
misoprostol treatment (control group) or, additionally, receive vaginally IMN as
well as the misoprostol treatment.
RESULTS: The mean induction to complete abortion interval was 20.4 h [95%
confidence interval (CI)=16.63-24.17] in the misoprostol group compared with 12.4
h (95% CI=10.33-14.47) in the misoprostol plus IMN group. This difference was
statistically significant (p<.05). In the subgroups of nulliparas and multiparas,
the shortening effect of the IMN was also statistically significant.
CONCLUSIONS: A net benefit after the combined use of IMN and misoprostol was
noted. Therefore, we believe that IMN has a clinical role in the ripening
process.
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