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Effect of zonisamide on essential tremor: a pilot crossover study in comparison with arotinolol.

Author(s): Morita S, Miwa H, Kondo T

Affiliation(s): Department of Neurology, Wakayama Medical University, 811-1 Kimiidera, Wakayama 641-8510, Japan.

Publication date & source: 2005-03, Parkinsonism Relat Disord., 11(2):101-3.

Publication type: Clinical Trial; Randomized Controlled Trial

We performed a pilot, crossover trial of zonisamide (ZNS) on essential tremor patients. Patients were randomly selected to start either ZNS or arotinolol treatment for 2 weeks. After a washout period, the patients were switched to an alternative drug. The assessment of tremor was carried out using the Fahn-Tolosa-Marin's clinical rating scale for tremor at baseline and 2 weeks after administration of each drug. There was a significant improvement after ZNS and arotinolol administration compared with the baseline. There was no significant difference in the antitremor effect between ZNS and arotinolol; however, ZNS was more effective for tremors of cranial nerve areas. Although the number of enrolled patients was limited in the present study, this open-label pilot study suggests that ZNS may have a therapeutic potential for essential tremor. A controlled trial of this drug in the future would be valuable.

Page last updated: 2006-01-31

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