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[Report of a case effectively treated by appropriate therapy for severe anticipatory nausea and vomiting due to FOLFOX or FOLFIRI]

Author(s): Mori M, Kiba T, Oikawa M, Hokkoku K, Watanabe Y, Nakagawa T, Shintaku K, Yoshimitsu Y, Sakuma H, Ueda H, Nakai M

Affiliation(s): Dept. of Pharmacy, Houju Memorial Hospital.

Publication date & source: 2009-02, Gan To Kagaku Ryoho., 36(2):325-7.

Publication type: Case Reports; English Abstract

To date, the standard treatments for severe anticipatory nausea and vomiting is not well established. 5-HT3 antagonist is one of the effective drugs to reduce chemotherapy-induced nausea and vomiting, but had no effect on these symptoms for this patient. The patient could be successfully administered standard chemotherapy(FOLFOX or FOLFIRI, q2w)without adverse reactions by appropriate treatments in the form of increased doses of dexamethasone and normal dose administration of prochlorperazine. This report suggests a possibility that FOLFOX or FOLFIRI may be successfully treated by appropriate treatments for severe chemotherapy-induced vomiting colon cancer patients, and that this observation may lead to the improved prognosis of these patients.

Page last updated: 2009-10-20

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