Comparative study of intranasal midazolam and intravenous diazepam sedation for procedures and seizures.

Author(s): Mittal P, Manohar R, Rawat AK

Affiliation(s): Department of Pediatrics, S.S. Medical College and G.M. Hospital, Rewa, India.

Publication date & source: 2006-11, Indian J Pediatr., 73(11):975-8.

Publication type: Comparative Study; Randomized Controlled Trial

OBJECTIVE: To evaluate the safety and efficacy of intranasal midazolam for seizures and various procedures. METHODS: Prospective randomized study. Total 125 children of all ages of either sex, for seizure episode (n-76) and various invasive and non-invasive procedures (n-49) received either intranasal midazolam (0.2 mg/Kg) or intravenous diazepam (0.3 mg/Kg). RESULTS. Mean time from arrival at hospital to starting treatment was significantly shorter in midazolam group compared to diazepam group [2.34+/-0.90; minute vs 4.61+/-1.08 minute p< 0.001]. Mean time to control seizures after arrival in hospital was significantly shorter in midazolam group compared to diazepam group [5.25+/-0.86 minute vs 6.51+/-1.06 minute p. CONCLUSION: Midazolam by the intranasal route provides safe and equally effective non-invasive method of sedation for procedures and seizures.