Effect of eslicarbazepine acetate and oxcarbazepine on cognition and psychomotor function in healthy volunteers.
Author(s): Milovan D, Almeida L, Romach MK, Nunes T, Rocha JF, Sokowloska M, Sellers EM, Soares-da-Silva P
Affiliation(s): Kendle Early Stage, Toronto, ON, Canada.
Publication date & source: 2010-08, Epilepsy Behav., 18(4):366-73. Epub 2010 Jun 18.
Publication type: Randomized Controlled Trial; Research Support, Non-U.S. Gov't
The results of two single-blind studies conducted to evaluate the cognitive and psychomotor effects of eslicarbazepine acetate and oxcarbazepine following single and repeated administration in healthy volunteers are reported. The cognitive and psychomotor evaluation consisted of several computerized and paper-and-pencil measures. Eslicarbazepine acetate and oxcarbazepine had similar overall cognitive profiles and did not cause clinically relevant cognitive impairment. The incidence of adverse events was lower with eslicarbazepine acetate than with oxcarbazepine. Copyright 2010. Published by Elsevier Inc.