No influence of pantoprazole on the pharmacokinetics of phenytoin.
Author(s): Middle MV, Muller FO, Schall R, Groenewoud G, Hundt HK, Huber R, Bliesath H, Steinijans VW
Affiliation(s): FARMOVS Institute for Clinical Pharmacology and Drug Development, University of the Orange Free State, Bloemfontein, Republic of South Africa.
Publication date & source: 1995-05, Int J Clin Pharmacol Ther., 33(5):304-7.
Publication type: Clinical Trial; Randomized Controlled Trial
Twenty-three healthy, male volunteers completed this doubleblind, randomized, placebo controlled, 2-period crossover study to assess the influence of multiple doses of pantoprazole on single-dose phenytoin pharmacokinetics. During each treatment period, the volunteers received either one 40 mg pantoprazole tablet or placebo for 7 days. In addition, a single-dose of 300 mg (3 x 100 mg capsules) phenytoin sodium was administered on day 4 of each treatment period. A 14-day wash-out period was allowed between phenytoin administrations. The results indicate that pantoprazole neither affects the rate nor the extent of absorption, nor the elimination of phenytoin.
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