Corneal ulceration and perforation with ketorolac tromethamine (Acular) use after PRK.

Author(s): Mian SI, Gupta A, Pineda R 2nd

Affiliation(s): University of Michigan, W. K. Kellogg Eye Center, Ann Arbor, Michigan 48105, USA. smian@med.umich.edu

Publication date & source: 2006-02, Cornea., 25(2):232-4.

Publication type: Case Reports

PURPOSE: To report a case of corneal ulceration and perforation after PRK connected with high doses of ketorolac tromethamine (Acula). METHODS: A 31-year-old man presented 5 days after PRK in the left eye with corneal ulceration and perforation requiring penetrating keratoplasty. The patient admitted to using Acular every hour, ciprofloxocin every hour, and prednisolone acetate 1% QID postoperatively. RESULTS: Laboratory tests, including corneal cultures, were normal. A diagnosis of corneal ulceration secondary to incorrect use of high-dose ketorolac tromethamine was made. CONCLUSION: Judicious patient counseling is recommended when using topical NSAIDs in the setting of PRK.