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Celecoxib does not appear to affect prosthesis fixation in total knee replacement: A randomized study using radiostereometry in 50 patients.

Author(s): Meunier A, Aspenberg P, Good L

Affiliation(s): Division of Orthopedics, Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Linkoping University, Sweden. andreas.meunier@lio.se

Publication date & source: 2009-02, Acta Orthop., 80(1):46-50.

Publication type: Randomized Controlled Trial; Research Support, Non-U.S. Gov't

BACKGROUND AND PURPOSE: After joint replacement, a repair process starts at the interface between bone and cement. If this process is disturbed, the prosthesis may never become rigidly fixed to the bone, leading to migration-and with time, loosening. Cox-2 inhibitors are widely used as postoperative analgesics, and have adverse effects on bone healing. This could tamper prosthesis fixation. We investigated whether celecoxib, a selective Cox-2 inhibitor, increases prosthesis migration in total knee replacement (TKR). METHODS: 50 patients were randomized to either placebo or celecoxib treatment, 200 mg twice daily, for 3 weeks after TKR (NexGen; Zimmer). Maximum total point motion (MTPM) of the tibial component was measured after 2 years using radiostereometric analysis (RSA). In addition, range of motion, pain, and, subjective outcome were evaluated. RESULTS: No differences in prosthesis migration, pain scores, range of motion, and subjective outcome were found after 2 years. Confidence intervals were narrow. INTERPRETATION: It is unlikely that Celecoxib increases the risk of loosening, and it may be used safely in conjunction with TKR.

Page last updated: 2009-10-20

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