Bullous drug eruption to griseofulvin in a man with Hailey-Hailey disease.

Author(s): Meffert JJ, Davis BM, Campbell JC

Affiliation(s): Department of Dermatology, Wilford Hall Medical Center, Lackland AFB, Texas, USA.

Publication date & source: 1995-11, Cutis., 56(5):279-80.

Publication type: Case Reports

Hailey-Hailey disease (chronic benign familial pemphigus) is a blistering disease characterized by episodic maceration and erosions in areas subject to friction and trauma such as the neck, axilla, and other intertriginous areas. We report a case in which a griseofulvin-induced drug eruption led to a generalized vesiculobullous eruption requiring treatment in a burn treatment center. This emphasizes that Hailey-Hailey disease, usually confined to relatively small areas, has the potential to cause blistering throughout the epidermis under certain conditions.