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The effects of clozapine and risperidone on spatial working memory in schizophrenia.

Author(s): McGurk SR, Carter C, Goldman R, Green MF, Marder SR, Xie H, Schooler NR, Kane JM

Affiliation(s): Department of Psychiatry, Mount Sinai School of Medicine, One Gustave L. Levy Pl., New York, NY 10029, USA. susan.r.mcgurk@dartmouth.edu

Publication date & source: 2005-05, Am J Psychiatry., 162(5):1013-6.

Publication type: Clinical Trial; Randomized Controlled Trial

OBJECTIVE: The purpose of this investigation was to evaluate the effects of clozapine and risperidone on spatial working memory in patients with schizophrenia. METHOD: Spatial working memory performance was evaluated at baseline and after 17 and 29 weeks in 97 patients with schizophrenia participating in a multisite trial. RESULTS: Compared with baseline performance while receiving conventional antipsychotic medication, risperidone improved, and clozapine worsened, spatial working memory performance. CONCLUSIONS: The differential effects of these medications on spatial working memory may be due to the anticholinergic effects of clozapine and prefrontal dopamine-enhancing effects of risperidone.

Page last updated: 2006-01-31

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