Modafinil effects on cognitive function in HIV+ patients treated for fatigue: a placebo controlled study.
Author(s): McElhiney M, Rabkin J, Van Gorp W, Rabkin R
Affiliation(s): Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, NY, USA. mcelhin@pi.cpmc.columbia.edu
Publication date & source: 2010-06, J Clin Exp Neuropsychol., 32(5):474-80. Epub 2009 Nov 24.
Publication type: Randomized Controlled Trial; Research Support, N.I.H., Extramural
Both mild cognitive impairment and fatigue are common among people with HIV/AIDS. This study examined the efficacy of modafinil for HIV+ patients who sought treatment for fatigue in a placebo-controlled double-blind 4-week trial. A battery of standard neuropsychological tests was administered at study entry and Week 4, and change in performance was compared for 59 patients receiving modafinil versus 44 patients receiving placebo. A significant effect on fatigue was observed. In addition, cognitive performance, as measured by a global change score, improved more in the modafinil than in the placebo group although the effect was not specific to any cognitive domain.
|