Effects of alcohol and cigarette smoking on change in serum estrone levels in postmenopausal women randomly assigned to fixed doses of conjugated equine estrogens with or without a progestin.

Author(s): McDivit AM, Greendale GA, Stanczyk FZ, Huang MH

Affiliation(s): The Cleveland Clinic, General Internal Medicine, Cleveland, OH, USA.

Publication date & source: 2008-03, Menopause., 15(2):382-5.

Publication type:

OBJECTIVE: To determine the effects of alcohol and smoking on serum estrone levels among women assigned to hormone therapy. DESIGN: We analyzed the data from 676 participants in the Postmenopausal Estrogen/Progestin Interventions study. RESULTS: Those who consumed more than 5.5 g of alcohol daily demonstrated greater rises in serum estrone than those who drank less (>0 to < or =5.5 g/d) (P = 0.07) and those who were abstinent (P = 0.09). Current smokers had lesser gains in serum estrone compared with former smokers (P < 0.0001) and never smokers (P < 0.0001). CONCLUSIONS: Alcohol consumption augmented and smoking diminished serum estrone levels achieved while women were taking hormone therapy.