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10-Hydroxynortriptyline and treatment effects in elderly depressed patients.

Author(s): McCue RE, Georgotas A, Suckow RF, Cooper TB

Affiliation(s): Department of Psychiatry, New York University School of Medicine, New York 10016.

Publication date & source: 1989-03, J Neuropsychiatry Clin Neurosci., 1(2):176-80.

Publication type: Clinical Trial; Comparative Study ; Randomized Controlled Trial; Research Support, U.S. Gov't, P.H.S.

Sixty-four elderly depressed outpatients were treated with nortriptyline for seven weeks. Plasma nortriptyline and its main metabolite, 10-hydroxynortriptyline, were measured weekly. No relationship was found between levels of 10-hydroxynortriptyline and clinical response. Plasma levels of the trans isomer, E-10-hydroxynortriptyline, were significantly lower when dizziness and symptoms of orthostatic hypotension were reported, although there was no significant correlation with actual orthostatic drop in systolic pressure. Plasma level of 10-hydroxynortriptyline was not significantly correlated with the other reported side effects.

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