Changes in body composition with ritonavir-boosted and unboosted atazanavir treatment in combination with Lamivudine and Stavudine: a 96-week randomized, controlled study.

Author(s): McComsey G, Rightmire A, Wirtz V, Yang R, Mathew M, McGrath D

Affiliation(s): Department of Pediatrics, Case Western Reserve University, Cleveland, Ohio, USA.

Publication date & source: 2009-05-01, Clin Infect Dis., 48(9):1323-6.

Publication type: Randomized Controlled Trial; Research Support, Non-U.S. Gov't

This 96-week, open-label, randomized study assessed changes in body composition in treatment-naive patients infected with human immunodeficiency virus type 1 who were treated with either atazanavir or ritonavir-boosted atazanavir, in combination with stavudine and lamivudine. Both treatment groups had similar increases in trunk fat, but patients treated with ritonavir-boosted atazanavir had a significantly lower incidence of lipoatrophy.