Effect of preoperative administration of tepoxalin on induction dose of injectable anesthetics in dogs.

Author(s): Matthews NS, Belz KM, Fosgate GT, Pappas C Jr

Affiliation(s): Texas A & M University, Department of Small Animal Medicine and Surgery, College of Veterinary Medicine, College Station, TX 77843-4474, USA.

Publication date & source: 2007-03, Vet Ther., 8(1):5-17.

Publication type: Randomized Controlled Trial; Research Support, Non-U.S. Gov't

Medications given preoperatively have the potential to affect the induction dose of injectable anesthetics, which could result in an anesthetic overdose. Tepoxalin is an NSAID approved for the treatment of arthritis in dogs in the United States and hence could be administered in patients requiring anesthesia. In this study, administration of a single dose or a 10-day course of tepoxalin did not affect the induction dose (dose that allowed intubation) of propofol, thiopental, or ketamine-diazepam and also did not affect the time required for dogs to recover from anesthesia.