Genotyping of CYP2B6 and therapeutic drug monitoring in an HIV-infected patient with high efavirenz plasma concentrations and severe CNS side-effects.
Author(s): Mathiesen S, Justesen US, Von Luttichau HR, Hansen AB
Affiliation(s): Department of Infectious Diseases, Rigshospitalet, Copenhagen University Hospital, Copenhagen. sofiemath@stud.ku.dk
Publication date & source: 2006, Scand J Infect Dis., 38(8):733-5.
Publication type: Case Reports
We present a case with important pharmacogenetic and pharmacokinetic aspects of antiretroviral therapy in a patient with high efavirenz concentrations, severe CNS side-effects and low lopinavir concentrations. Despite therapeutic drug monitoring and subsequent efavirenz dosage reductions, side-effects did not resolve completely and lopinavir concentrations remained relatively low.
|