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Efficacy and tolerability of zonisamide in idiopathic generalized epilepsy.

Author(s): Marinas A, Villanueva V, Giraldez BG, Molins A, Salas-Puig J, Serratosa JM

Affiliation(s): Fundacion Jimenez Diaz, Madrid, Spain.

Publication date & source: 2009-03, Epileptic Disord., 11(1):61-6. Epub 2009 Mar 5.

Publication type: Multicenter Study

OBJECTIVE: The objective of this study is to evaluate the efficacy and safety of zonisamide (ZNS) for the treatment of idiopathic generalized epilepsies (IGEs). METHODS: Thirteen patients with different types of IGEs who were treated with ZNS between the years 2006 and 2008 were identified. Efficacy and tolerability were assessed at months 6 and 12 post-treatment. Response was defined as a 50% or greater reduction in seizure frequency. RESULTS: Twelve patients (92.3%) continued with ZNS at month 6, and 11 (84.6%) at month 12. Mean daily dose was 319 mg (range 100-500 mg/d). Response was achieved at month 6 in eight of the 12 patients that continued with ZNS (66.6%), of which 7 were seizure-free (58.3%). At month 12, eight of the 11 patients that continued with ZNS were responders (72.7%) and 6 were seizure-free (63.6%). For different types of seizures, better responses were observed for absences and generalized tonic-clonic seizures. Four out of 13 patients (30.7%) experienced adverse events and in two (15.3%), these led to withdrawal. CONCLUSION: In this retrospective study, ZNS showed efficacy and tolerability for the treatment of different types of IGEs. Limitations include a small sample size and a relatively short period of follow-up. Our results are promising and justify the need for prospective controlled trials in IGE.

Page last updated: 2009-10-20

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