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Continuous propofol administration for suxamethonium-induced postoperative myalgia.

Author(s): Manataki AD, Arnaoutoglou HM, Tefa LK, Glatzounis GK, Papadopoulos GS.

Affiliation(s): Department of Anaesthesiology, G. Hatzikosta General Hospital, Ioannina, Greece.

Publication date & source: 1999, Anaesthesia. , 54(5):419-22

The effect of continuous propofol administration on creatine kinase and suxamethonium-induced postoperative myalgia was evaluated in 50 patients randomised into two groups of 25 patients each. Induction of anaesthesia was identical in all patients. Anaesthesia was maintained with 66% nitrous oxide in oxygen supplemented by either isoflurane 1% or continuous propofol. Creatine kinase was measured before and after operation. Myalgia was evaluated postoperatively by a blinded observer. The median level of myalgia was reduced significantly in the continuous propofol group (p = 0.011). The median creatine kinase value increased significantly in the isoflurane group (from 90 to 160 IU, p = 0.001).

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