Effects of Nigella sativa oil with a low-calorie diet on cardiometabolic risk
factors in obese women: a randomized controlled clinical trial.
Author(s): Mahdavi R(1), Namazi N, Alizadeh M, Farajnia S.
Affiliation(s): Author information:
(1)Nutrition Research Center, Faculty of Nutrition, Tabriz University of Medical
Sciences, Tabriz, Iran.
Publication date & source: 2015, Food Funct. , 6(6):2041-8
Obesity is typically associated with increased risk factors of cardiovascular
diseases (CVDs). Therefore, a therapeutic approach that aims to control body
weight and metabolic profile might be effective in preventing CVDs. We aimed to
determine the effects of Nigella Sativa (NS) oil with a low-calorie diet on
cardiometabolic risk factors in obese women. In this double-blind randomized
controlled clinical trial, 90 obese women were recruited. Participants were
females aged 25-50 years old with body mass index (BMI) between 30 and 35 kg
m(-2). They were randomly assigned to receive a low-calorie diet with 3 g per day
(1 g before each meal) NS oil or placebo for 8 weeks. Anthropometric indices,
dietary intake and biochemical parameters were measured at the baseline and after
the intervention. Eighty-four females completed the trial (intervention n = 43,
placebo n = 41). Two groups were similar in the baseline characteristics. After
the intervention, dietary intake was changed in both groups compared to the
baseline, but the differences were not significant between the two groups. In the
NS group, weight (-6.0 vs. -3.6%; p < 0.01) and waist circumference (-6.9 vs.
-3.4%; p < 0.01) decreased significantly compared with the placebo group at the
end of the trial. Comparison of biochemical parameters presented a significant
decline in triglyceride (-14.0 vs. 1.4%; p = 0.02) and very low density
lipoprotein (-14.0 vs. 7%; p < 0.01) levels in the NS group compared to the
placebo group. NS oil concurrent with a low-calorie diet can reduce
cardiometabolic risk factors in obese women. However, more clinical trials are
needed to elucidate efficacy of NS as a complementary therapy in obese subjects.
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