The effect of azelastine on exercise-induced asthma.

Author(s): Magnussen H, Reuss G, Jorres R, Aurich R

Affiliation(s): Zentrum fur Pneumologie und Thoraxchirurgie, Krankenhaus Grosshansdorf, West Germany.

Publication date & source: 1988-05, Chest., 93(5):937-40.

Publication type: Clinical Trial; Randomized Controlled Trial

In ten young asthmatic subjects, we studied the effect of a single oral dose of 4.4 mg of azelastine hydrochloride on exercise-induced bronchoconstriction during the breathing of cold air. Exercise challenges were performed on two different days before and four hours after azelastine and placebo given in a randomized double-blind crossover fashion. Placebo had no effect on baseline pulmonary function and postexertional obstruction of the airways, in contrast to azelastine, which exerted a small but significant (p less than 0.05) bronchodilation and a significant attenuation (p less than 0.01) of exercise-induced bronchoconstriction as compared to data from before treatment and after placebo.