Indapamide is superior to thiazide in the preservation of renal function in patients with renal insufficiency and systemic hypertension.

Author(s): Madkour H, Gadallah M, Riveline B, Plante GE, Massry SG

Affiliation(s): Division of Nephrology, University of Southern California School of Medicine, Los Angeles, USA.

Publication date & source: 1996-02-22, Am J Cardiol., 77(6):23B-25B.

Publication type: Clinical Trial; Multicenter Study; Randomized Controlled Trial

The long-term effects of indapamide or hydrochlorothiazide on blood presssure and renal function were examined in patents with impaired renal function and moderate hypertension. Both drugs controlled hypertension and blood pressure remained normal during the 2 years of the study. Despite this comparable control of hypertension, indapamide therapy was associated with a 28.5 +/- 4.4% increase in creatinine clearance, whereas treatment with hydrochlorothiazide was associated with a 17.4 +/- 3.0% decrease in creatinine clearance. The results of the study indicate that indapamide is superior to hydrochlorothiazide in the treatment of patients with impaired renal function and moderate hypertension.