Arthrogryposis multiplex congenita and bilateral mid-brain infarction following maternal overdose of co-proxamol.

Author(s): Maalouf EF, Battin M, Counsell SJ, Rutherford MA, Manzur AY

Affiliation(s): Department of Paediatrics and Neonatal Medicine, Imperial College School of Medicine, Hammersmith Hospital, London, UK.

Publication date & source: 1997, Eur J Paediatr Neurol., 1(5-6):183-6.

Publication type: Case Reports

We report a case of arthrogryposis multiplex congenita secondary to fetal hypokinesia in a 41-week gestation infant following antenatal central nervous system injury. The mother's pregnancy was complicated by an episode of attempted self harm, with an overdose of co-proxamol at 22 weeks of gestational age, and by the use of cocaine in combination with excess alcohol intake. Magnetic resonance imaging showed bilateral mid-brain cysts and marked atrophy of the basal ganglia and thalami.