Psychosis in a 12-year-old HIV-positive girl with an increased serum concentration of efavirenz.
Author(s): Lowenhaupt EA, Matson K, Qureishi B, Saitoh A, Pugatch D
Affiliation(s): Department of Psychiatry and Human Behavior, Brown Medical School, Providence, RI, USA. elowenhaupt@post.harvard.edu
Publication date & source: 2007-11-15, Clin Infect Dis., 45(10):e128-30. Epub 2007 Oct 5.
Publication type: Case Reports
Clearance and adverse effects of efavirenz are associated with CYP2B6-G516T polymorphism. Little is known about the prevalence of genotypes and implications for screening in children. We report (to our knowledge, for the first time in a child) the emergence of psychosis in a 12-year old white girl with an increased efavirenz concentration and heterozygous gene polymorphism of the CYP2B6-G516T.
|