Nonsurgical treatment of patients with periodontal disease.

Author(s): Loesche WJ, Giordano J, Soehren S, Hutchinson R, Rau CF, Walsh L, Schork MA

Affiliation(s): University of Michigan School of Dentistry, Ann Arbor, USA.

Publication date & source: 1996-05, Oral Surg Oral Med Oral Pathol Oral Radiol Endod., 81(5):533-43.

Publication type: Clinical Trial; Randomized Controlled Trial

OBJECTIVE. To determine whether the short-term use of systemic antimicrobials (metronidazole or doxycycline) and locally delivered antimicrobials (metronidazole, chlorhexidine) in patients with advanced forms of periodontal disease could prevent the normally necessary access surgery. STUDY DESIGN. Ninety-four patients were randomly assigned with the use of a double-blind protocol. RESULTS. There was a 93% reduction in the need for periodontal surgery about individual teeth and an 81% reduction in the need for tooth extractions. Only 93 teeth of an initial total of 783 teeth actually needed surgery or extractions. Eighty-one percent of the patients entered into the maintenance phase of treatment without needing surgical treatments. CONCLUSION. These findings indicate that a treatment paradigm based on the diagnosis and treatment of anaerobic infections is likely to be successful in those patients for whom access surgery is recommended.