Repurposing of yunnan baiyao as an alternative therapy for minor recurrent
aphthous stomatitis.
Author(s): Liu X, Guan X, Chen R, Hua H, Liu Y, Yan Z.
Affiliation(s): Department of Oral Medicine, School and Hospital of Stomatology, Peking
University, Beijing 100081, China.
Publication date & source: 2012, Evid Based Complement Alternat Med. , 2012:284620
The study was designed to evaluate the efficacy and safety of an herbal extract
of Yunnan Baiyao formulated in toothpaste as an alternative therapy for minor
RAS. A randomized, double-blind, placebo-controlled clinical trial (from March
2010 to March 2011) was conducted on a cohort of 227 minor RAS patients. The
toothpaste containing Yunnan Baiyao was used twice daily as part of the patient's
routine oral hygiene for 5 days. An assessment of ulcerative size and pain was
recorded on day 0 (baseline), day 3, and day 5. Any noted adverse reactions were
recorded. All data were analyzed using the SAS software 8.0. As a result, the
toothpaste containing Yunnan Baiyao began to present noticeable effectiveness on
ulcer healing (ulcer size) by day 3 (27.5% versus 15.8%, P < 0.05), which further
improved by day 5 when compared to the placebo (66.4% versus 50.0%, P = 0.01). A
significant difference in alleviating pain was noted on day 5 for those who used
the toothpaste containing Yunnan Baiyao (66.4% versus 51.8%, P < 0.05). No side
effects were noted as a result of the Yunnan Baiyao. Therefore, Yunnan Baiyao may
provide an alternative therapy for minor ulcers by promoting healing.
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