[Effect of valsartan on postprandial plasma inflammatory factors in patients with essential hypertension]

Author(s): Liu L, Zhao SP, Zhou HN, Xu DY, Li JX

Affiliation(s): Department of Cardiology, Second Xiangya Hospital, Central South University, Changsha 410011, China. feliuling@medmail.com.cn

Publication date & source: 2008-09, Zhong Nan Da Xue Xue Bao Yi Xue Ban., 33(9):809-13.

Publication type: English Abstract; Randomized Controlled Trial; Research Support, Non-U.S. Gov't

OBJECTIVE: To explore the effect of valsartan on the concentrations of plasma inflammatory factors after a high-fat meal in patients with essential hypertension in very short time. METHODS: Fifty hypertensive patients and 25 healthy controls were studied. Patients randomly accepted lacidipine 4 mg/d (lacidipine group) or valsartan 80 mg/d (valsartan group) for 1 week. The concentrations of plasma lipid profiles, high-sensitivity C-reactive protein (hsCRP) and soluble P-selectin were measured in fasting state and at 4 h after a single high-fat meal in all subjects at baseline and in patients after 1 week. RESULTS: The concentrations of postprandial plasma hsCRP and soluble P-selectin significantly increased after a high-fat meal in patients (P < 0.05), as compared with those at fasting levels, but not in the controls. The postprandial plasma triglyceride concentrations significantly increased in the healthy controls (P < 0.05), but were lower than those in hypertensive patients (P < 0.01). Postprandial change in plasma concentration of triglyceride was significantly correlated with those of log (hsCRP) (r = 0.344)and soluble P-selectin (r = 0.432), respectively (n = 75, both P < 0.01). Lipids profiles did not change significantly after 1 week. There was no significant difference between the fasting and postprandial plasma concentrations of either hsCRP or soluble P-selectin in valsartan group, while the postprandial increments of inflammatory factors were still significant in the lacidipine group. CONCLUSION: High-fat meal can induce postprandial inflammation response in patients with essential hypertension. Valsartan effectively attenuates this postprandial inflammation response within a very short time.