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Efficacy of domestic bisoprolol,enalapril and nifedipine retard in mild to moderate hypertension: a randomized double-blind multicenter clinical trial in China.

Author(s): Liu G, Li M, Shi X, Et Al

Affiliation(s): Department of Cardiology, The General Hospital of PLA, Beijing 100853, China.

Publication date & source: 2002-07, Zhonghua Nei Ke Za Zhi., 41(7):450-2.

Publication type: Clinical Trial; Randomized Controlled Trial

OBJECTIVE: To compare the efficacy and tolerability of bisoprolol, enalapril and nifedipine retard in the treatment of mild to moderate essential hypertension. METHODS: This is a randomized, double-blind, multicenter clinical trial. 331 patients with mild to moderate hypertension in the army troop were randomly allocated to receive domestic bisoprolol ( n =110,5 mg/d),enalapril ( n =111,10 mg/d) and nifedipine retard ( n =110,20 mg/day). Total duration of active drug treatment was 4 weeks. RESULTS: The total efficacy rates of domestic bisoprolol, enalapril and nifedipine retard were 80.0%, 82.0% and 81.8% respectively P > 0.05 . The incidences of adverse events were 4.5%, 8.1% and 19.1% (P < 0.01 ) in patients of bisoloprol, enalapril and nifedipine retard groups respectively. The adverse effects were mild in all the three groups. CONCLUSIONS: Domestic bisoprolol, enalapril and nifedipine retard are effective and well-tolerated in patients with mild to moderate essential hypertension. The occurrence of adverse effects were least in the bisoprolol group and most in the nifedipine retard group.

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