Acetaminophen in the treatment of headaches associated with dipyridamole-aspirin combination.

Author(s): Lipton RB, Bigal ME, Kolodner KB, Gorelick PB, Wilks K, Schoebelock M, Davidai G

Affiliation(s): Department of Neurology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA. Rlipton@aecom.yu.edu

Publication date & source: 2004-09-28, Neurology., 63(6):1099-101.

Publication type: Clinical Trial; Multicenter Study; Randomized Controlled Trial

The authors assessed the prevalence of headaches following extended-release dipyridamole/aspirin combination (DAC), and the efficacy of acetaminophen in the treatment of these headaches. Following DAC, 38.7% of the participants developed headaches. The headaches were self-limited (69.4% placebo efficacy in 2 hours) and the incidence markedly declined over time. Acetaminophen was no more effective than placebo in the acute and preemptive treatment of these headaches.