[The effects of angiotensin II and other noradrenergic vasoconstrictors on the blood flow in Yoshida rat ascites hepatoma AH 109 A at same electrode position]

Author(s): Li YL, Hori K, Saito S, Tanda S, Suzuki M

Affiliation(s): Dept. of Experimental Oncology, Tohoku University.

Publication date & source: 1990-03, Gan To Kagaku Ryoho., 17(3 Pt 2):548-53.

The differing effects of angiotensin II (AT II) and five other vasoactive agents on the tissue blood flow in Yoshida rat ascites hepatoma AH 109 A were studied at the same electrode position by a hydrogen clearance method. The elevation of blood pressure by AT II resulted in a 3.4-fold increases in the tumor blood flow. However, when AT II was reinfused, it resulted in only 2.1, 2.2, 2.3, 1.9 and 2.4-fold increases, respectively, after infusion of methoxamine, norepinephrine, metaraminol, epinephrine, and phenylephrine. A pronounced reduction and further reducing tendency in the tumor blood flow were found after administration of norepinephrine and epinephrine. In addition, metaraminol, phenylephrine, and methoxamine did not change significantly the blood flow of the tumor. The results of this present blood flow study further suggest that AT II acts more peripherally in the host vascular bed from which newly growing tumor vessels bud than other vasoconstrictors do.