[Comparison of the effectiveness of levofloxacin and cefuroxime for the treatment of sinusitis]

Author(s): Li XP, Qin ZM, Zheng RH, Tan QL, Zhou YY, Zhu L, Yin AF

Affiliation(s): Department of Otolaryngology, Third Hospital, Beijing University, Beijing 100083.

Publication date & source: 2000-12, Lin Chuang Er Bi Yan Hou Ke Za Zhi., 14(12):573-5.

Publication type: Clinical Trial; Randomized Controlled Trial

OBJECTIVE: To observe the effectiveness of levofloxacin and cefuroxime for the treatment of sinusitis in adults. METHOD: Patients with acute or chronic sinusitis were randomly assigned to receive either levofloxacin (200 mg orally once daily, 200/100 mg twice daily) or cefuroxime (250 mg orally twice daily) for 10 to 14 days. Pre- or post-treatment, the clinical and laboratory examination were done and in the end of treatment, the efficacy and safety were assessment. RESULT: The success rates after the end of treatment were 97.4% for the 76 patients who received levofloxacin and 92.8% for the 14 patients who received cefuroxime. The resolution rates of bacteria were 91.6% and 80.0%, respectively. The safety of these two groups were more high. CONCLUSION: Levofloxacin is effective for the treatment of sinusitis in adults and pay attention to the course of treatment for raising the efficacy of treatment.