Penicillamine-induced elastosis of the mucosal lip.

Author(s): Lewis BK, Chern PL, Stone MS

Affiliation(s): Department of Internal Medicine, University of Utah Hospitals and Clinics, Salt Lake City, Utah, USA.

Publication date & source: 2009-04, J Am Acad Dermatol., 60(4):700-3.

Publication type: Case Reports

Long-term penicillamine therapy has been associated with alterations in dermal elastic tissue. Well-described associated dermatoses include pseudo-pseudoxanthoma elasticum, acquired cutis laxa, elastosis perforans serpiginosa, and anetoderma. Histologically, "lumpy-bumpy"" or "bramble-bush"" morphologic changes of elastic fibers in the dermis are characteristic. Previous reports of these findings in normal-appearing skin and internal organs suggest a systemic elastolytic process. Here we report an unusual case of penicillamine-induced elastosis affecting the mucosa of the lip with characteristic histologic features.