Prostacyclins in diabetes: an electrophysiological study.
Author(s): Lessel MR(1), Thaler A, Scheiber V, Heilig P, Gottlob I, Schernthaner G.
Affiliation(s): Author information:
(1)Department of Ophthalmology, University of Vienna, Austria.
Publication date & source: 1993, Ophthalmic Res. , 25(6):355-62
Twelve patients with juvenile (insulin-dependent, type I) diabetes were treated
either with prostacyclins or placebo in a double-masked randomized study. The
electroretinogram (ERG) was recorded before, 1 day and 8 months after treatment.
An analysis of variance and covariance was carried out to evaluate possible
treatment or time effects on the a and b waves and the oscillatory potentials of
the ERG. Mean values of potentials displayed a decrease of amplitude and an
increase of latency over the follow-up period in all patients. No statistically
significant difference between treated and placebo groups could be proven.
|