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Prostacyclins in diabetes: an electrophysiological study.

Author(s): Lessel MR(1), Thaler A, Scheiber V, Heilig P, Gottlob I, Schernthaner G.

Affiliation(s): Author information: (1)Department of Ophthalmology, University of Vienna, Austria.

Publication date & source: 1993, Ophthalmic Res. , 25(6):355-62

Twelve patients with juvenile (insulin-dependent, type I) diabetes were treated either with prostacyclins or placebo in a double-masked randomized study. The electroretinogram (ERG) was recorded before, 1 day and 8 months after treatment. An analysis of variance and covariance was carried out to evaluate possible treatment or time effects on the a and b waves and the oscillatory potentials of the ERG. Mean values of potentials displayed a decrease of amplitude and an increase of latency over the follow-up period in all patients. No statistically significant difference between treated and placebo groups could be proven.

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