DrugLib.com — Drug Information Portal

Rx drug information, pharmaceutical research, clinical trials, news, and more



Glatiramer acetate attenuates neuropathic allodynia through modulation of adaptive immune cells.

Author(s): Leger T, Grist J, D'Acquisto F, Clark AK, Malcangio M

Affiliation(s): Wolfson Centre for Age Related Disease, Kings College London, London, UK.

Publication date & source: 2011-05, J Neuroimmunol., 234(1-2):19-26. Epub 2011 Feb 4.

Publication type: Research Support, Non-U.S. Gov't

Immune-neuronal interactions contribute to neuropathic pain. Thus, immune-competent cells such as microglia may provide targets for pain relief, as may infiltrating lymphocytes. We evaluated the nature of the lymphocyte response in the spinal cord in association with the maintenance of neuropathic allodynia. We assessed T cell contribution to pain processing by targeting these cells with Glatiramer acetate (GA) which when administered systemically reversed neuropathic allodynia, inhibited microglia response and increased IL-10 and IL-4 expressing T cells in neuropathic dorsal horns. These studies advance understanding of lymphocyte contribution to chronic pain and reveal a new mechanism of T cell intervention. Copyright (c) 2011 Elsevier B.V. All rights reserved.

Page last updated: 2011-12-09

-- advertisement -- The American Red Cross
 
Home | About Us | Contact Us | Site usage policy | Privacy policy

All Rights reserved - Copyright DrugLib.com, 2006-2017