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Multicentre trial of antepartum low-dose anti-D immunoglobulin.

Author(s): Lee D, Rawlinson VI

Affiliation(s): Manchester Blood Centre, Plymouth Grove, U.K.

Publication date & source: 1995-03, Transfus Med., 5(1):15-9.

Publication type: Clinical Trial; Multicenter Study; Randomized Controlled Trial

Routine antenatal Rh immunoprophylaxis would substantially increase the use of anti-D Ig in the U.K. As availability of anti-D Ig is one factor influencing a decision to introduce routine antenatal prophylaxis, a trial was undertaken to test the efficacy of a lower dose of anti-D Ig than that used in earlier studies. RhD-negative primigravidae were randomized as controls or recipients of two doses of 250iu of anti-D Ig given at 28 and 34 weeks gestation. Blood samples were tested at delivery and at 6 months postpartum for the presence of immune anti-D, and again later if results were equivocal. Nine (1.5%) out of 595 control patients had immune anti-D at follow-up at 6 months and later; 4 (0.78%) of 513 treated women were immunized. It was concluded that, while two doses of 250iu of anti-D Ig may reduce alloimmunization, they are not as effective as two doses of 500iu in a previous trial.

Page last updated: 2006-01-31

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