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Pharmacological and clinical studies on purine nucleoside analogs--new anticancer agents.

Author(s): Lech-Maranda E, Korycka A, Robak T

Affiliation(s): Department of Hematology, Medical University of Lodz and Copernicus Memorial Hospital, 93-513 Lodz, Pabianicka 62, Poland.

Publication date & source: 2006-05, Mini Rev Med Chem., 6(5):575-81.

Publication type: Research Support, Non-U.S. Gov't ; Review

More recently, three novel purine nucleoside analogs, including clofarabine, nelarabine and immucillin H, have been introduced into clinical trials. These agents have different metabolic properties, novel mechanism of action, and are undergoing phase I-II clinical studies for the treatment of hematopoietic malignancies. Pharmacology and anticancer activity of PNA are the subjects of this review.

Page last updated: 2007-05-02

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