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[Intravenous versus oral treatment of endogenously depressed patients with doxepin--a double-blind study with plasma level determination]

Author(s): Laux G, Konig W, Lesch KP, Stein A

Affiliation(s): Psychiatrischen Universitatsklinik Wurzburg, BRD.

Publication date & source: 1989-11-30, Wien Med Wochenschr., 139(22):525-9.

Publication type: Clinical Trial; Comparative Study ; English Abstract; Randomized Controlled Trial

A double-blind study was conducted involving 45 "therapy-resistant" endogenous depressive inpatients who were treated with Doxepin intravenously or orally. After a period of 3 weeks there was no significant difference in the clinical ratings (HRSD, SDS). In the parenteral treatment group, however there was a statistically significant quicker onset of action (day 3). Compared to oral application higher Doxepin plasma concentrations during day 1 to 6 could be obtained by drip-infusion in spite of lower dosage.

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