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Assessment of the effectiveness of drug therapies on nutritional status in the elderly: "concerning a randomised, double-blind clinical study of the activity of pancreatic extracts and a placebo during the renutrition of elderly subjects suffering from protein caloric undernutrition".

Author(s): Lauque S, Nourhashemi F, Baudouin M, Ghisolfi-Marque A, Beziat F, Moreau J, Dyard F, Vellas B, Albarede JL

Affiliation(s): Department of Internal Medicine and Clinical Gerontology, University Hospital, Toulouse, France.

Publication date & source: 1998, J Nutr Health Aging., 2(1):18-20.

Publication type: Clinical Trial; Randomized Controlled Trial

AIMS: to study, versus placebo, the value of administering pancreatic extracts in elderly subjects suffering from denutrition. METHODS: 52 subjects over 70 years of age, living in the Toulouse region of France, were included in this study. Each subject was required to present with an impaired nutritional status of their food intake, anthropometric and laboratory markers. RESULTS: among the 52 patients included in the study, 26 received the placebo and 26 received a pancreatic extract (Creon 12,000). 88% of these patients were women and 12% were men, the mean age of patients was 87+/-6 years. The groups were comparable at entry into the study. Nutritional intake increased in the two groups. There was a non-significant increase in body weight in the treated group when compared with the placebo group. DISCUSSION: we think that in the future, it would be preferable to conduct studies in convalescent subjects, reducing the frequency of nutritional assessments (food intake on D0 and D90, to reduce interference with the patient's habits.

Page last updated: 2006-01-31

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