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Moclobemide in depression: a randomized, multicentre trial against isocarboxazide and clomipramine emphasizing atypical depression.

Author(s): Larsen JK, Gjerris A, Holm P, Anderson J, Bille A, Christensen EM, Hoyer E, Jensen H, Mejlhede A, Langagergaard A

Affiliation(s): Department of Psychiatry, Frederiksberg Hospital, Denmark.

Publication date & source: 1991-12, Acta Psychiatr Scand., 84(6):564-70.

Publication type: Clinical Trial; Comparative Study ; Randomized Controlled Trial

Moclobemide was compared with isocarboxazide and clomipramine in patients with depression. A total of 167 outpatients were allocated to daily treatment with 300 mg moclobemide, 30 mg isocarboxazide or 150 mg clomipramine for 6 weeks. Moclobemide was slightly inferior to clomipramine, whereas isocarboxazide had an intermediate position. There was no interaction between treatment and atypical or nonatypical depression. Anticholinergic symptoms and orthostatic hypotension were most pronounced in the clomipramine group.

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