Low-dose aspirin in non-tubal IVF patients with previous failed conception: a prospective randomized double-blind placebo-controlled trial.

Author(s): Lambers MJ, Hoozemans DA, Schats R, Homburg R, Lambalk CB, Hompes PG

Affiliation(s): Department of Obstetrics, Gynecology and Reproductive Medicine Free University Medical Center, Amsterdam, The Netherlands.

Publication date & source: 2008-10-28, Fertil Steril., [Epub ahead of print]

Publication type:

OBJECTIVE: To analyze whether the administration of low-dose aspirin during IVF treatment improves the uterine blood flow and improves ongoing pregnancy rates for non-tubal factor IVF patients with previous failed conception. DESIGN: Prospective double-blind placebo-controlled trial. SETTING: University fertility clinic. PATIENT(S): Non-tubal IVF patients with previous failed conception. INTERVENTION(S): Daily 100 mg aspirin or placebo throughout an IVF treatment with a long GnRH-agonist stimulation protocol. MAIN OUTCOME MEASURE(S): Ongoing pregnancy rate, pulsatility index of the uterine artery. RESULT(S): Of 169 patients, 84 were assigned to aspirin treatment and 85 to placebo treatment. In the aspirin group, 28 patients (35.4%) had an ongoing pregnancy, and in the placebo group, 26 patients (31.0%) had an ongoing pregnancy. Multilevel analyses showed that the pulsatility index of the uterine artery was not affected by aspirin or placebo treatment. CONCLUSION(S): Low-dose aspirin administration during IVF treatment does not improve pregnancy rates of non-tubal factor IVF patients with previous failed conception, and it does not affect the arterial uterine blood flow.