Sublingual versus oral misoprostol for uterine evacuation following early pregnancy failure.

Author(s): Kushwah B, Singh A

Affiliation(s): Lady Harding Medical College, Delhi, India. baps_aps@yahoo.com

Publication date & source: 2009-07, Int J Gynaecol Obstet., 106(1):43-5. Epub 2009 May 7.

Publication type: Comparative Study; Randomized Controlled Trial

OBJECTIVE: To compare the efficacy of misoprostol administered sublingually or orally for uterine evacuation after early pregnancy failure. METHOD: Forty-eight hours after receiving 200 mg of mifepristone orally, 100 women were randomized to receive misoprostol sublingually or orally. RESULTS: The evacuation rates were 92% in the sublingual and 84% in the oral administration group; the mean+/-SD induction-to-evacuation intervals were 5.6+/-4.54 hours and 9.44+/-5.61 hours, this difference being significant; and the adverse effects were similar in the 2 groups. CONCLUSION: The sublingual route was found to be as effective but faster than the oral route for uterine evacuation after early pregnancy failure.