[Laboratory and clinical studies on cefdinir (10% fine granules) in pediatric field]

Author(s): Kuno K, Ogawa A, Takeuchi H, Tomita K, Kitoh O, Andoh H, Takimoto Y

Affiliation(s): Department of Pediatrics, Anjo Kosei Hospital.

Publication date & source: 1991-10, Jpn J Antibiot., 44(10):1134-41.

Publication type:

Clinical studies on 10% fine granules of cefdinir (CFDN), a new cephem antibiotic, were carried out in the field of pediatrics. The results obtained are summarized as follows. 1. Half-lives of CFDN in plasma in 3 children when administered on an empty stomach were 1.77 hours (3 mg/kg per os) and 1.47 hours (6 mg/kg per os), respectively. Eight hour urinary excretion rates of CFDN were 21.5% (3 mg/kg per os) and 16.4% (6 mg/kg per os), respectively. 2. CFDN was administered to 11 children with various bacterial infections: 1 patient with scarlet fever, 1 with pharyngotonsillitis, 3 with acute bronchitis, 3 with pneumonia and 3 with urinary tract infections. The overall clinical efficacy rate was 90.9%. 3. Loose stool was noted in 1 patient. No abnormal laboratory test values were encountered.