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Dithranol irritation in psoriasis treatment: a study of 68 inpatients.

Author(s): Kucharekova M, Lieffers L, van de Kerkhof PC, van der Valk PG

Affiliation(s): Department of Dermatology, University Medical Centre St Radboud, PO Box 9101, 6500 HB Nijmegen, The Netherlands. mku@sder.azm.nl

Publication date & source: 2005-03, J Eur Acad Dermatol Venereol., 19(2):176-9.

The irritant response of perilesional skin is a serious limitation of dithranol therapy in psoriasis. No data are available on the actual prevalence and severity of irritation during 24-h dithranol treatment in an inpatient setting. Using a retrospective analysis of 68 patients with psoriasis visiting our inpatient department for dithranol treatment, the occurrence of dithranol irritation was studied. We found a relatively high frequency of dithranol irritation. Furthermore, most irritation occurs at the start of the therapy with relatively low concentrations.

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