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Six weeks phylloquinone supplementation produces undesirable effects on blood lipids with no changes in inflammatory and fibrinolytic markers in postmenopausal women.

Author(s): Kristensen M, Kudsk J, Bugel S

Affiliation(s): Dept. of Human Nutrition, Centre for Advanced Food Studies, University of Copenhagen, Rolighedsvej 30, 1958, Frederiksberg C, Denmark. mekr@life.ku.dk

Publication date & source: 2008-10, Eur J Nutr., 47(7):375-9. Epub 2008 Sep 17.

Publication type: Randomized Controlled Trial; Research Support, Non-U.S. Gov't

BACKGROUND: Cardiovascular disease is the major cause of death in the Western world, but some recent studies indicate that vitamin K may play a role in atherosclerosis protection. AIM OF STUDY: The aim of this study was to evaluate the effect of phylloquinone supplementation on blood lipids, inflammatory markers and fibrinolytic activity in postmenopausal women. METHODS: Thirty-one postmenopausal women completed this placebo-controlled, randomized crossover study and received 500 microg phylloquinone or placebo in addition to their habitual diet during two periods of 6 weeks' duration. Blood concentration of lipids, inflammatory markers and fibrinolytic parameters were measured after each period. RESULTS: Inflammatory markers, fibrinolytic parameters, total cholesterol and LDL-C were unaffected by the supplementation, whereas a 15% increase was seen in triacylglycerols (P = 0.015) and a 5% decrease in HDL-C (P = 0.06). CONCLUSIONS: Six weeks supplementation with a dose of phylloquinone similar to that obtainable from the diet induced a deterioration of the lipid profile with no improvement in any of the other risk markers analysed. Thus, these results do not support a cardioprotective effect of vitamin K as has been suggested by others.

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