[Analgesia in colon surgery : Can the use of NSAIDs reduce the opioid consumption following conventional and laparoscopic interventions?]

Author(s): Kraft B, Leroy S, Schweizer M, Junginger W, Bittner R

Affiliation(s): Abteilung fur Allgemein- und Visceralchirurgie, Marienhospital, Boheimstrasse 37, 70199 , Stuttgart, barbarakraft@vinzenz.de.

Publication date & source: 2006-10, Chirurg., 77(10):913-918.

Publication type:

BACKGROUND: The goal of our study was to evaluate the morphine-sparing effect of nonsteroidal anti-inflammatory drugs (NSAIDs) following both conventional and laparoscopic colon surgery.MATERIALS AND METHODS: In this prospective, randomized clinical trial, 180 patients were assigned to three groups. Two groups received either paracetamol or parecoxib/valdecoxib in addition to piritramid via patient-controlled or nurse-controlled analgesia pump. Patients in the control group received piritramid only. The total piritramid consumption during hospital stay was recorded.RESULTS: Total opioid consumption was significantly lower in the two groups who received NSAIDs. Comparing conventional and laparoscopic surgery, the latter group had much lower opioid consumption.CONCLUSION: The use of NSAIDs following colon surgery significantly reduces postoperative opioid consumption.