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Clomipramine increases the incidence and duration of spike-wave discharges in freely moving WAG/Rij rats.

Author(s): Kovacs Z, Czurko A, Kekesi KA, Juhasz G

Affiliation(s): Department of Zoology, University of West Hungary Savaria Campus, Szombathely, Karolyi Gaspar ter 4, 9700 Hungary. zskovacs@ttmk.nyme.hu

Publication date & source: 2010-06, Epilepsy Res., 90(1-2):167-70. Epub 2010 Mar 17.

Publication type: Research Support, Non-U.S. Gov't

PURPOSE: The noradrenergic and serotonergic system may have a role in modulation of absence seizures. We investigated whether the single injection of monoamine reuptake inhibitor clomipramine has an acute effect on spike-wave discharge (SWD) activity in Wistar Albino Glaxo/Rijswijk (WAG/Rij) rats. METHODS: We injected a single dose of 20 or 50 mg/kg clomipramine intraperitoneally into WAG/Rij rats and measured the incidence and duration of SWD episodes for 4h after injection. The changes in SWDs were compared to the preceding 5-day average control level. RESULTS: The 20 mg/kg clomipramine significantly increased the incidence of SWDs in the first measured hour while the 50 mg/kg dose significantly increased the incidence and duration of SWDs in the whole measured 4-h period. CONCLUSIONS: Clomipramine, by acutely elevating synaptic monoamine levels, could exacerbate absence seizures. Copyright (c) 2010 Elsevier B.V. All rights reserved.

Page last updated: 2010-10-05

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